Why Be One Protein When You Can Affect Many? The Multiple Roles of YB-1 in Lung Cancer and Mesothelioma.

摘要: Lung cancers and malignant pleural mesothelioma (MPM) have some of the worst 5-year survival rates all cancer types, primarily due to a lack effective treatment options for most patients. Targeted therapies shown promise in thoracic cancers, although efficacy is limited only patients harboring specific mutations or target expression. Although number actionable now been identified, large population no therapeutic outside first-line chemotherapy. It therefore crucial identify alternative targets that might lead development new ways treating diagnosed with these diseases. The multifunctional oncoprotein Y-box binding protein-1 (YB-1) could serve as one such target. Recent studies also link this protein many inherent behaviors cells proliferation, invasion, metastasis involvement stem-like cells. Here, we review regulation YB-1 at transcriptional, translational, post-translational sub-cellular levels discuss its potential use biomarker