Light-induced engagement of microglia to focally remodel synapses in the adult brain.
作者： Carla Cangalaya , Stoyan Stoyanov , Klaus-Dieter Fischer , Alexander Dityatev
DOI: 10.7554/ELIFE.58435
关键词:
摘要: Microglia continuously monitor synapses, but active synaptic remodeling by microglia in mature healthy brains is rarely directly observed. We performed targeted photoablation of single synapses transgenic mice expressing fluorescent labels neurons and microglia. The photodamage focally increased the duration microglia-neuron contacts, dramatically exacerbated both turnover dendritic spines presynaptic boutons as well generation new filopodia originating from spine heads or boutons. results depletion confirmed that elevated are microglia-dependent processes.
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sci-hub.st 参考文章(48)
Monica R.P. Elmore, Allison R. Najafi, Maya A. Koike, Nabil N. Dagher, Elizabeth E. Spangenberg, Rachel A. Rice, Masashi Kitazawa, Bernice Matusow, Hoa Nguyen, Brian L. West, Kim N. Green, Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain Neuron. ,vol. 82, pp. 380- 397 ,(2014) , 10.1016/J.NEURON.2014.02.040
M. Fuhrmann, G. Mitteregger, H. Kretzschmar, J. Herms, Dendritic Pathology in Prion Disease Starts at the Synaptic Spine The Journal of Neuroscience. ,vol. 27, pp. 6224- 6233 ,(2007) , 10.1523/JNEUROSCI.5062-06.2007
Dimitrios Davalos, Jaime Grutzendler, Guang Yang, Jiyun V Kim, Yi Zuo, Steffen Jung, Dan R Littman, Michael L Dustin, Wen-Biao Gan, ATP mediates rapid microglial response to local brain injury in vivo Nature Neuroscience. ,vol. 8, pp. 752- 758 ,(2005) , 10.1038/NN1472
Stephen Mok, Richard C. Koya, Christopher Tsui, Jingying Xu, Lídia Robert, Lily Wu, Thomas G. Graeber, Brian L. West, Gideon Bollag, Antoni Ribas, Inhibition of CSF-1 receptor improves the antitumor efficacy of adoptive cell transfer immunotherapy Cancer Research. ,vol. 74, pp. 153- 161 ,(2014) , 10.1158/0008-5472.CAN-13-1816
Guoping Feng, Rebecca H. Mellor, Michael Bernstein, Cynthia Keller-Peck, Quyen T. Nguyen, Mia Wallace, Jeanne M. Nerbonne, Jeff W. Lichtman, Joshua R. Sanes, Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP. Neuron. ,vol. 28, pp. 41- 51 ,(2000) , 10.1016/S0896-6273(00)00084-2
Sharon E Haynes, Gunther Hollopeter, Guang Yang, Dana Kurpius, Michael E Dailey, Wen-Biao Gan, David Julius, The P2Y12 receptor regulates microglial activation by extracellular nucleotides Nature Neuroscience. ,vol. 9, pp. 1512- 1519 ,(2006) , 10.1038/NN1805
P. Thevenaz, U.E. Ruttimann, M. Unser, A pyramid approach to subpixel registration based on intensity IEEE Transactions on Image Processing. ,vol. 7, pp. 27- 41 ,(1998) , 10.1109/83.650848
A. L. Allegra Mascaro, P. Cesare, L. Sacconi, G. Grasselli, G. Mandolesi, B. Maco, G. W. Knott, L. Huang, V. De Paola, P. Strata, F. S. Pavone, In vivo single branch axotomy induces GAP-43–dependent sprouting and synaptic remodeling in cerebellar cortex Proceedings of the National Academy of Sciences of the United States of America. ,vol. 110, pp. 10824- 10829 ,(2013) , 10.1073/PNAS.1219256110
Anthony J.G.D. Holtmaat, Joshua T. Trachtenberg, Linda Wilbrecht, Gordon M. Shepherd, Xiaoqun Zhang, Graham W. Knott, Karel Svoboda, Transient and Persistent Dendritic Spines in the Neocortex In Vivo Neuron. ,vol. 45, pp. 279- 291 ,(2005) , 10.1016/J.NEURON.2005.01.003
Kathryn M. Lenz, Margaret M. McCarthy, A Starring Role for Microglia in Brain Sex Differences The Neuroscientist. ,vol. 21, pp. 306- 321 ,(2015) , 10.1177/1073858414536468