The transferrin receptor.

摘要: Transferrin receptor (TfR) is a membrane involved in the control of iron supply to cell through binding transferrin, major iron-carrier protein. This plays key role proliferation because essential for sustaining ribonucleotide reductase activity, and only enzyme that catalyzes conversion ribonucleotides deoxyribonucleotides. Furthermore, TfR overexpressed several tumors. The synthesis controlled an iron-dependent negative feedback cells where proliferation, but positive types storage (monocytes-macrophages). Recent studies have shed light on molecular basis by which regulates expression. Thus, 3' untranslated region mRNA contains cis-acting RNA element, termed iron-regulatory element (IRE), interacts with IRE-binding protein (IRE-BP). high-affinity interaction between IRE-BP IRE leads repression degradation thus higher TfR. Hence, study activity will elucidate mechanisms modulate expression normal malignant cells.