Ras, Ral, and Rap1 in C. elegans.
作者： David J Reiner , Neal R Rasmussen
DOI: 10.1007/978-1-0716-1190-6_26
关键词:
摘要: Characterizing the consequences of mutated Ras/LET-60 on development C. elegans vulva has provided critical insights into role Ras in normal animal development. Furthermore, double mutant analysis revealed relative to other components growth factor signal transduction. Here we describe combined use principles parallelism and epistasis investigate different effectors, Raf RalGEF > Ral, during tissues. We additionally these delineate function close relative, RAP-1. The worm continues lead way clarifying otherwise poorly understood functions
sci-hub.st 参考文章(51)
W S Katz, G M Lesa, D Yannoukakos, T R Clandinin, J Schlessinger, P W Sternberg, A POINT MUTATION IN THE EXTRACELLULAR DOMAIN ACTIVATES LET-23, THE CAENORHABDITIS ELEGANS EPIDERMAL GROWTH FACTOR RECEPTOR HOMOLOG Molecular and Cellular Biology. ,vol. 16, pp. 529- 537 ,(1996) , 10.1128/MCB.16.2.529
Stuart K. Kim, David M. Eisenmann, Mechanism of Activation of the Caenorhabditis Elegans Ras Homologue Let-60 by a Novel, Temperature-Sensitive, Gain-of-Function Mutation Genetics. ,vol. 146, pp. 553- 565 ,(1997) , 10.1093/GENETICS/146.2.553
Ravi S Kamath, Maruxa Martinez-Campos, Peder Zipperlen, Andrew G Fraser, Julie Ahringer, Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in Caenorhabditis elegans Genome Biology. ,vol. 2, pp. 1- 10 ,(2000) , 10.1186/GB-2000-2-1-RESEARCH0002
Helen M. Chamberlin, James Hagman, Daniel Fitzsimmons, Andrew D. Johnson, EGL-38 Pax regulates the ovo-related gene lin-48 during Caenorhabditis elegans organ development. Development. ,vol. 128, pp. 2857- 2865 ,(2001) , 10.1242/DEV.128.15.2857
S Brenner, THE GENETICS OF CAENORHABDITIS ELEGANS Genetics. ,vol. 77, pp. 71- 94 ,(1974) , 10.1093/GENETICS/77.1.71
Edwin L Ferguson, H Robert Horvitz, Identification and Characterization of 22 Genes That Affect the Vulval Cell Lineages of the Nematode CAENORHABDITIS ELEGANS Genetics. ,vol. 110, pp. 17- 72 ,(1985) , 10.1093/GENETICS/110.1.17
John Yochem, Nomarski images for learning the anatomy, with tips for mosaic analysis. Wormbook. pp. 1- 47 ,(2006) , 10.1895/WORMBOOK.1.100.1
Paul W. Sternberg, H.Robert Horvitz, Pattern formation during vulval development in C. elegans. Cell. ,vol. 44, pp. 761- 772 ,(1986) , 10.1016/0092-8674(86)90842-1
Yuliya Pylayeva-Gupta, Elda Grabocka, Dafna Bar-Sagi, RAS oncogenes: weaving a tumorigenic web Nature Reviews Cancer. ,vol. 11, pp. 761- 774 ,(2011) , 10.1038/NRC3106
Kerry Kornfeld, Dennis B. Hom, H.Robert Horvitz, The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans Cell. ,vol. 83, pp. 903- 913 ,(1995) , 10.1016/0092-8674(95)90206-6