COG1410, a novel apolipoprotein-E mimetic, improves functional and morphological recovery in a rat model of focal brain ischemia
作者： Elena A. Tukhovskaya , Alexey Yu. Yukin , Oksana N. Khokhlova , Arkady N. Murashev , Michael P. Vitek
DOI: 10.1002/JNR.21874
关键词:
摘要: Apolipoprotein E (apoE) is the primary apolipoprotein synthesized in brain response to injury with known neuroprotective effects exerted through antioxidant, antiinflammatory, antiexcitotoxic, and neurotrophic mechanisms. We have previously demonstrated that COG1410, an apoE mimetic peptide, exerts antiinflammatory a murine model of traumatic (TBI). As TBI, ischemia-reperfusion component acute stroke, which displays pharmacogenetic association APOE4 gene. Using intraluminal middle cerebral occlusion (MCAO) rats, we found single intravenous injection COG1410 at 120 min post-MCAO significantly improved vestibulomotor function, decreased poststroke locomotor asymmetry, infarct volume ipsilateral hemisphere. These results support further exploration novel apoE-mimetic as therapeutic treatment for stroke.
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