Natural products as leads to anticancer drugs.

摘要: Throughout history, natural products have afforded a rich source of compounds that found many applications in the fields medicine, pharmacy and biology. Within sphere cancer, number important new commercialised drugs been obtained from sources, by structural modification compounds, or synthesis designed following compound as model. The search for improved cytotoxic agents continues to be an line discovery modern anticancer drugs. huge diversity their bioactivity potential meant several isolated plants, marine flora microorganisms can serve “lead” improvement therapeutic molecular modification. Additionally, semisynthesis processes functional groups lead are able generate analogues with greater pharmacological activity fewer side effects. These processes, complemented high-throughput screening protocols, combinatorial chemistry, computational chemistry bioinformatics afford far more efficient than those currently used clinical practice. Combinatorial biosynthesis is also applied microbial products. Likewise, advances genomics advent biotechnology both production compounds.