Preoperative Risk Score and Prediction of Long-Term Outcomes after Hepatectomy for Intrahepatic Cholangiocarcinoma

摘要: Background Accurate prediction of prognosis for patients with intrahepatic cholangiocarcinoma (ICC) remains a challenge. We sought to define preoperative risk tool predict long-term survival after resection ICC. Study Design Patients who underwent hepatectomy ICC at 1 16 major hepatobiliary centers between 1990 and 2015 were identified. Clinicopathologic data analyzed prognostic model was developed based on the regression β-coefficients in training set. The subsequently assessed using validation Results Among 538 patients, most had solitary tumor (median number 1; interquartile range 2) median size 5.7 cm (interquartile 4.0 8.0 cm). Median 5-year overall 39.0 months 39.0%, respectively. On multivariable analyses, factors associated included (hazard ratio [HR] 1.12; 95% CI 1.06 1.18), natural logarithm carbohydrate antigen 19-9 level (HR 1.33; 1.22 1.45), albumin 0.76; 0.55 0.99), neutrophil lymphocyte 1.05; 1.02 1.09). A weighted composite score constructed these factors: [9 + (1.12 × size) + (2.81 × 19-9) + (0.50 × ratio) + (−2.79 × albumin)]. demonstrated good performance testing (area under curve 0.696) (0.691) datasets. performed better than both T categories 0.532) cumulative stage classifications American Joint Committee Cancer staging manual, 8th edition 0.559). When assessing death within year operation, ≥25 positive predictive value 59.8% compared 35.3% T4 disease 31.8% IIIB disease. Conclusions Postsurgical outcomes could be predicted scoring system clinical parameters. can used inform patient provider conversations expectations before operation.