RNA interference in adult mice
作者： Anton P. McCaffrey , Leonard Meuse , Thu-Thao T. Pham , Douglas S. Conklin , Gregory J. Hannon
DOI: 10.1038/418038A
关键词:
摘要: RNA interference is an evolutionarily conserved surveillance mechanism that responds to double-stranded by sequence-specific silencing of homologous genes. Here we show transgene expression can be suppressed in adult mice synthetic small interfering RNAs and small-hairpin transcribed vivo from DNA templates. We also the therapeutic potential this technique demonstrating effective targeting a sequence hepatitis C virus vivo.
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