The DEAD-box helicase Vasa: Evidence for a multiplicity of functions in RNA processes and developmental biology

作者: Paul Lasko

DOI: 10.1016/J.BBAGRM.2013.04.005

关键词:

摘要: DEAD-box helicases related to the Drosophila protein Vasa (also known as Ddx4) are found throughout animal kingdom. They have been linked numerous processes in gametogenesis, germ cell specification, and stem biology, alterations expression associated with malignancy of tumor cells some human male infertility syndromes. Experimental results indicating how contributes all these different cellular developmental discussed, using examples from planarians, Caenorhabditis elegans, Drosophila, sea urchin, zebrafish, Xenopus, mouse, human. Molecular, cellular, functions its orthologs reviewed this article. Evidence linking translational regulation, biogenesis small RNAs, chromosome condensation is examined. Finally, potential overlapping between (Belle, or Ddx3, DEADSouth, Ddx25) explored. This article part a Special Issue entitled: The biology RNA - Modulation for life.

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