Oversecretion and Overexpression of Nicotinamide Phosphoribosyltransferase/Pre-B Colony-Enhancing Factor/Visfatin in Inflammatory Bowel Disease Reflects the Disease Activity, Severity of Inflammatory Response and Hypoxia
作者： Katarzyna Neubauer , Iwona Bednarz-Misa , Ewa Walecka-Zacharska , Jaroslaw Wierzbicki , Anil Agrawal
DOI: 10.3390/IJMS20010166
关键词:
摘要: Nicotinamide phosphoribosyltransferase’s (Nampt) association with inflammatory bowel disease (IBD) is unclear. The study was aimed at unraveling Nampt’s clinical and diagnostic relevance. serum concentration (Luminex-xMAP® technology) measured in 113 patients Crohn’s (CD), 127 ulcerative colitis (UC) 60 non-IBD controls: 40 healthy individuals 20 irritable syndrome (IBS). leukocyte (44 CD/37 UC/19 IBS) expression (186 samples) also evaluated (RT-qPCR). All were referred to IBD phenotype, activity, treatment, inflammatory/nutritional/angiogenic/hypoxia indices. Serum-Nampt leukocyte-Nampt positively correlated more elevated active-IBD than IBS, being a fair differential marker. UC its endoscopic activity as well pro-inflammatory cytokines. ≤1.54 ng/mL good indicator of mucosal healing. Nampt up-regulated both inflamed quiescent colon reflected, similarly leukocyte-Nampt, the IBD. Bowel-Nampt independently associated IL1B hypoxia-inducible factor 1α (HIF1A) but FGF2 bowel. In summary, elevation local systemic levels, protein mRNA reflects inflammation, hypoxia (active) tissue repair (inactive disease).
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