Human Lacrimal Gland Secretes Proteins Belonging to the Group of Hydrophobic Molecule Transporters

摘要: Many orbital glands and ocular surface epithelia participate to the formation of human lacrimal tear film: main gland, accessory glands, goblet cells conjunctival epithelial cells, cornea meibomian glands. Consequently, tears are constituted a complex mixture proteins glycoproteins, with or without enzymatic activities, metabolites, electrolytes lipids. Furthermore, serum proteins, generally accepted as derived from vessels indicative collection trauma, also present. Three gland lactoferrin, lysozyme specific prealbumin account for major part protein content. Our presentation will deal prealbumin, which is, further demonstrated, an inappropriate term. Bonavida, Sapse Sercarz (1969) described, first time, present at high levels in humans several animal species (rabbit, rat, monkey). Its electrophoretic mobility was larger than albumin it absent other biological fluids such cerebrospinal fluid, saliva, nasal secretion sweat. local synthesis by shown culturing slices presence radiolabeled amino-acids (Bonavida et al., 1969). Using higher resolution methods, we demonstrated that Bonavida’s team had not described single but group least six whose molecular weight ranged 15 20 kDa isoelectric points ranging 4.6 5.4 (Gachon 1979; Gachon, Lambin Dastugue, 1980); called them ‘Proteins Migrating Faster Albumin’ (PMFAs) order clearly differentiate transthyretin (current denomination prealbumin).