The effect of hypercapnic acidosis preconditioning on rabbit myocardium

摘要: This study observed the protective effect of hypercapnic acidosis preconditioning on rabbit heart suffered from ischemia-reperfusion injury. Hypercapnic was established in animals with mechanical hypoventilation before ischemia-reperfusion. Thirty-two rabbits were randomly divided into 4 groups, each having 8 aminals term degree acidification: group A (group A), B B), C C), ischemia and reperfusion IR). Animals IR ventilated normally (tidal volume: 15 mL/kg, breathing rate 35 bpm). The PETCO2 maintained at level 40–50 mmHg for 30 min. groups A, B, received low-frequency, low-volume ventilation to achieve hypercarbonic target levels 75–85,65–75, 55–65 mmHg, respectively, being 5 then lower mmHg. left anterior branch artery all ligated min reperfused 180 Then infarct size calculated. cardiomyocytes morphologically ECG hemodynamics monitored continuous basis. Acid-base balance measured during procedure. Our results showed that (48.5±11.5)% risk area control (42.4±7.9)% (P>0.05). Mean significantly smaller (34.5%±9.4%) (P<0.05 vs group) (31.0%±9.1%) (P<0.01 group). It is concluded HA-preconditioning can effectively protect myocardium.