Cost-Effectiveness of Adolescent Pertussis Vaccination for The Netherlands: Using an Individual-Based Dynamic Model

摘要: BACKGROUND: Despite widespread immunization programs, a clear increase in pertussis incidence is apparent many developed countries during the last decades. Consequently, additional strategies are considered to reduce burden of disease. The aim this study design an individual-based stochastic dynamic framework model transmission population order predict epidemiologic and economic consequences implementation universal booster vaccination programs. Using framework, we estimate cost-effectiveness adolescent at age 12 years Netherlands. METHODS/PRINCIPAL FINDINGS: We designed discrete event simulation (DES) epidemiological implementing vaccination. used national age-specific notification data over period 1996-2000--corrected for underreporting--to calibrate assuming steady state situation. Subsequently, was introduced. Input parameters were derived from literature, sources (e.g. costing data, hospitalization data) expert opinions. As there no consensus on duration immunity acquired by natural infection, two scenarios protection (i.e. 8 15 years). In both scenarios, total decreased as result From societal perspective, estimated €4418/QALY (range: 3205-6364 € per QALY) €6371/QALY 4139-9549 8- 15-year respectively. Sensitivity analyses revealed that outcomes most sensitive quality life weights CONCLUSIONS/SIGNIFICANCE: To our knowledge first population. This indicates likely be cost-effective intervention suited investigate further strategies.