The Cell Cycle, DNA Replication, and Repair

作者: A.R. LEHMANN

DOI: 10.1016/B978-0-08-091882-2.50022-1

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摘要: Publisher Summary This chapter describes the cell cycle, DNA replication, and repair. The cycle is period during which duplicates its entire contents such that on subsequent division, each daughter contains all material originally present in parent at beginning of cycle. diploid human genome approximately 1010 base pairs distributed into 46 chromosomes. near-perfect replication these molecules effected confines nucleus time interval a few hours or less. ability to replicate lies complementary pair structure molecule. double-stranded molecule semiconservative, is, progeny one parental newly synthesized strand. accomplished by separation two strands synthesis new using separated strand as template. basic reaction nucleotide polymerization carried out polymerases.

参考文章(37)
Leon N. Kapp, Robert B. Painter, DNA Replication Fork Movement Rates in Mammalian Cells International Review of Cytology-a Survey of Cell Biology. ,vol. 80, pp. 1- 25 ,(1982) , 10.1016/S0074-7696(08)60365-4
Lynne Mayne, Alan R. Lehmann, Susan Kirk-Bell, Abnormal Kinetics of DNA Synthesis in Ultraviolet Light-irradiated Cells from Patients with Cockayne's Syndrome Cancer Research. ,vol. 39, pp. 4237- 4241 ,(1979)
H Ariga, S Sugano, Initiation of simian virus 40 DNA replication in vitro. Journal of Virology. ,vol. 48, pp. 481- 491 ,(1983) , 10.1128/JVI.48.2.481-491.1983
T Lindahl, DNA Repair Enzymes Annual Review of Biochemistry. ,vol. 51, pp. 61- 87 ,(1982) , 10.1146/ANNUREV.BI.51.070182.000425
Errol C. Friedberg, Ursula K. Ehmann, Jon I. Williams, Human Diseases Associated with Defective DNA Repair Advances in radiation biology. ,vol. 8, pp. 85- 174 ,(1979) , 10.1016/B978-0-12-035408-5.50008-3
Rosalind M. Yanishevsky, Gretchen H. Stein, Regulation of the Cell Cycle in Eukaryotic Cells International Review of Cytology-a Survey of Cell Biology. ,vol. 69, pp. 223- 259 ,(1981) , 10.1016/S0074-7696(08)62324-4
R. B. Setlow, Repair deficient human disorders and cancer Nature. ,vol. 271, pp. 713- 717 ,(1978) , 10.1038/271713A0
Joel A. Huberman, Arthur D. Riggs, On the mechanism of DNA replication in mammalian chromosomes Journal of Molecular Biology. ,vol. 32, pp. 327- 341 ,(1968) , 10.1016/0022-2836(68)90013-2