Two new proteases in the MHC class I processing pathway

作者: Lars Stoltze , Markus Schirle , Gerold Schwarz , Christian Schröter , Michael W. Thompson

DOI: 10.1038/80852

关键词:

摘要: … in the antigen-processing pathway for MHC class I molecules. … We also found that the generation of the OVA CTL epitope … inhibited by the cystein protease inhibitor E64 15,23 . …

参考文章(32)
M Del Val, D López, Selective involvement of proteasomes and cysteine proteases in MHC class I antigen presentation. Journal of Immunology. ,vol. 159, pp. 5769- 5772 ,(1997)
C. Enenkel, D.H. Wolf, BLH1 codes for a yeast thiol aminopeptidase, the equivalent of mammalian bleomycin hydrolase. Journal of Biological Chemistry. ,vol. 268, pp. 7036- 7043 ,(1993) , 10.1016/S0021-9258(18)53142-2
Jeffrey Shabanowitz, Jarrod A. Marto, Chance John Luckey, Teresa A. Colella, Donald F. Hunt, Gina M. King, Victoria L. Crotzer, Victor H. Engelhard, Sunita Venketeswaran, Bernhard F. Maier, Proteasomes Can Either Generate or Destroy MHC Class I Epitopes: Evidence for Nonproteasomal Epitope Generation in the Cytosol Journal of Immunology. ,vol. 161, pp. 112- 121 ,(1998)
Jonathan W. Yewdell, Jack R. Bennink, Angel Porgador, Marian Orlowski, Heidi L. Snyder, Luis C. Antón, Alexander Vinitsky, Dissociation of Proteasomal Degradation of Biosynthesized Viral Proteins from Generation of MHC Class I-Associated Antigenic Peptides Journal of Immunology. ,vol. 160, pp. 4859- 4868 ,(1998)
Radosveta P. Koldamova, Iliya M. Lefterov, Marc T. DiSabella, John S. Lazo, An Evolutionarily Conserved Cysteine Protease, Human Bleomycin Hydrolase, Binds to the Human Homologue of Ubiquitin-Conjugating Enzyme 9 Molecular Pharmacology. ,vol. 54, pp. 954- 961 ,(1998) , 10.1124/MOL.54.6.954
Niels P. N. Emmerich, Alexander K. Nussbaum, Stefan Stevanovic, Martin Priemer, René E. M. Toes, Hans-Georg Rammensee, Hansjörg Schild, The Human 26 S and 20 S Proteasomes Generate Overlapping but Different Sets of Peptide Fragments from a Model Protein Substrate Journal of Biological Chemistry. ,vol. 275, pp. 21140- 21148 ,(2000) , 10.1074/JBC.M000740200
E. Geier, G. Pfeifer, M. Wilm, M. Lucchiari-Hartz, W. Baumeister, K. Eichmann, G. Niedermann, A Giant Protease with Potential to Substitute for Some Functions of the Proteasome Science. ,vol. 283, pp. 978- 981 ,(1999) , 10.1126/SCIENCE.283.5404.978
Kirsten Falk, Olaf Rötzschke, Hans-Georg Rammensee, Cellular peptide composition governed by major histocompatibility complex class I molecules Nature. ,vol. 348, pp. 248- 251 ,(1990) , 10.1038/348248A0
Daniel B. Constam, Andreas R. Tobler, Anne Rensing-Ehl, Iris Kemler, Louis B. Hersh, Adriano Fontana, Puromycin-sensitive aminopeptidases Journal of Biological Chemistry. ,vol. 270, pp. 26931- 26939 ,(1996) , 10.1074/JBC.270.45.26931