On the absolute configuration of chiral 1,4-dihydropyridazines synthesized by organocatalysed reactions.

作者： Na Lin , Cristina Forzato , Federico Berti , Fulvia Felluga , Patrizia Nitti

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摘要: A computational investigation of the specific optical rotation and electronic circular dichroism spectra two chiral 1,4-dihydropyridazines was performed compared with existing experimental data to verify a previous assignment their absolute configuration based on well-accepted mechanism catalysis organocatalyst used in synthesis. Both calculations indicate that is opposite one assigned basis originally assumed. An alternative reaction therefore suggested.

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On the absolute configuration of chiral 1,4-dihydropyridazines synthesized by organocatalysed reactions.

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On the absolute configuration of chiral 1,4-dihydropyridazines synthesized by organocatalysed reactions.

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