The Genus Yersinia: Biochemistry and Genetics of Virulence With 3 Figures

摘要: A highly successful modus operandi in research is to perform an experiment and then decide what problem was solved; the alternative procedure of devising experiments order answer preexisting questions may be more difficult. Unfortunately, latter approach cannot avoided by those concerned with infectious diseases because question why a given microorganism virulent automatically framed its discoverer—in this case, plague bacillus Yersin (1894) causative agent pseudotuberculosis Malassez, Vignal (1883). The delay almost century obtaining satisfactory answers these simply illustrates that complexity host-parasite relationship formidable relevant expression virulence have not been designed. At same time, considerable progress towards end has made other pathogens, especially correlating nutritional requirements metabolic patterns bacterium’s favored habitat vivo (Moulder, 1962). Nevertheless, diverse phenomena observed during infection intracellular parasites always duplicated simplified experimental systems. Furthermore, infectivity many microorganisms low or erratic laboratory animals response normal host acute chronic phases disease quite distinct.