Assessment of LeadCare® II analysis for testing of a wide range of blood lead levels in comparison with ICP-MS analysis.

摘要: Abstract The LeadCare® testing system, which utilizes anodic stripping voltammetry (ASV) methodology, has been widely used worldwide for cost-effective blood lead level (BLL) screening. However, some concerns have recently issued regarding inaccurate results obtained using LeadCare®. Hence, we aimed to evaluate the accuracy of BLL measured by II (BLLLC) comparison with ICP-MS (BLLIM) Passing–Bablok regression, Deming and Bland–Altman analyses 994 venous samples. BLLLC ranged from 3.3 162.3 μg/dL, while BLLIM 0.8 154.8 μg/dL. Although exhibited a strong positive correlation, values were generally greater than values, indicative overestimation analysis. A large bias 19.15 ± 8.26 μg/dL 29.25 ± 14.04 μg/dL compared recorded in range 45.0–64.9 μg/dL ≥65.0 μg/dL, respectively. In contrast, ≤0.3 μg/dL was observed at less 10.0 μg/dL. Blood copper, cadmium, iron levels did not exhibit an effect on BLLLC, minimal potential interferences metals; these are cause concern ASV method. conclusion, analysis is thought be good tool screening purposes lower around reference 5 μg/dL initial stage; however, conversion or retesting laboratory analyzer recommended higher appropriate clinical evaluation research.