Impact of prolactin receptor isoforms on reproduction

摘要: Prolactin is a hormone involved in growth, development, reproduction, metabolism, water and electrolyte balance, brain behavior, immunoregulation. Its actions on reproductive processes represent the largest group of functions identified for this hormone. Besides classic long form prolactin receptor, many short receptors have been rodents human tissues. Mouse mutagenesis studies offered insight into biology family, providing compelling evidence that different isoforms independent biological activity. The possibility forms mediate cell proliferation important variety tissues including mammary glands ovarian follicles. This review summarizes current knowledge about signaling its role reproduction through either or isoform receptors.