Adipocytokines in anorexia nervosa: a review focusing on leptin and adiponectin.

摘要: Adipose tissue secretes a large number of physiologically active peptides that often share structural properties with cytokines, and are therefore collectively referred to as "adipocytokines". Some these almost exclusively secreted by adipose tissue. Leptin, adiponectin resistin specific fat-derived hormones affect fuel homeostasis insulin action, may also be involved in hematopoiesis immune functions. Anorexia nervosa is characterized chronic self-starvation severe weight loss, mainly at the expense Starvation-induced depletion fat stores accompanied alterations circulating adipocytokines. Plasma leptin likely levels decreased anorectic patients, while plasma increased. These have potential repercussions pathophysiology anorexia nervosa. Thus, low high separately or concert contribute altered immunity, enhanced sensitivity, neuroendocrine disturbances osteopenia