Gut Microbiota and Cardiovascular Uremic Toxicities

摘要: Cardiovascular disease (CVD) remains a major cause of high morbidity and mortality in patients with chronic kidney (CKD). Numerous CVD risk factors CKD have been described, but these do not fully explain the pervasiveness or increased rates patients. In loss urinary excretory function results retention various substances referred to as "uremic solutes". Many molecules found exert toxicity on virtually all organ systems human body, leading clinical syndrome uremia. recent years, an increasing body evidence has accumulated that suggests uremic toxins may contribute cardiovascular burden associated CKD. This review examined from several experimental studies showing association between CVD. Special emphasis is addressed emerging data linking gut microbiota production development The biological some myocardium vasculature their possible contribution injury uremia are also discussed. Finally, therapeutic interventions applied effectively reduce CKD, including dietary modifications, use prebiotics and/or probiotics, oral intestinal sorbent adsorbs precursors, innovative dialysis therapies targeting protein-bound highlighted. Future needed determine whether novel remove will related events long-term renal failure.