作者: John T. Prince , Natalie G. Ahn
DOI: 10.1016/J.MOLCEL.2010.02.010
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摘要: In this issue of Molecular Cell, Hoshi et al. (2010) report two examples in which small molecule inhibitors are rendered ineffective when their kinase targets involved protein-protein interactions, highlighting differences between vivo and vitro inhibition kinetics.