Synthesis, singlet oxygen photogeneration and DNA photocleavage of porphyrins with nitrogen heterocycle tails.
作者： Yun-Man Zheng , Kai Wang , Tian Li , Xiu-Lan Zhang , Zao-Yin Li
DOI: 10.3390/MOLECULES16053488
关键词:
摘要: Eight novel compounds were prepared by reaction of 5-(bromo- propoxyphenyl)-10,15,20-triphenylporphyrin with oxazole thiols, 1,3,4-oxadiazole thiols and 1,3,4-thiadiazole their structures confirmed UV-vis, IR, 1H-NMR, MS elemental analysis. The assessment indirectly measured 1O2 production rates against 5,10,15,20-tetraphenyl porphyrin (H2TPP) described the relative singlet oxygen yields were：porphyrin 5 > porphyrins 1, 3, 4, 6-8, H2TPP 2. Porphyrin 4 7 showed substantial photocleavage activities toward DNA, over 75% cleavage observed at 40 µM. It suggested that these those nitrogen heterocycle tails are potential photosensitive agents.
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