Clinical relevance of autophagic therapy in cancer: Investigating the current trends, challenges, and future prospects.

摘要: Oncophagy (cancer-related autophagy) has a complex dual character at different stages of tumor progression. It remains an important clinical problem to unravel the reasons that propel shift in role oncophagy from inhibition protective mechanism shields full-blown malignancy. Most treatment strategies emphasize curbing while triggering is lethal cells. In this review, we focus on trends current therapeutics as well various challenges trials address oncophagic dilemma and evaluate potential these developing therapies. A detailed analysis pre-clinical scenario anticancer medicines highlights inducers inhibitors autophagy. The ways which stage, microenvironment combination drug continue play tactical are discussed. Moreover, autophagy targets also crucial best possible solution paradox. provide comprehensive update impact autophagy-based cancer therapeutic drugs try lessen gap between translational medicine science.