The successful transfer of a modern CHO fed-batch process to different single-use bioreactors
作者： Sebastian Ruhl , Ute Husemann , Elke Jurkiewicz , Thomas Dreher , Gerhard Greller
DOI: 10.1186/1753-6561-7-S6-P32
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摘要: Nowadays, single-use bioreactors are widely accepted in pharmaceutical industry. This is based on shorter batch to times, reduced cleaning effort and a significantly lower risk of cross contaminations [1,2]. One large field the application seed train cultivation mammalian cells [1]. The focus further extended perform state art fed-batch production processes such bioreactors. In this study an industrial proven CHO process established different reusable
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