Identification of a new in vitro substrate of tyrosine protein kinase.
作者： Masaaki Tokuda , Siow Kee Kong , Navin C Khanna , David Morton Waisman , None
DOI: 10.1021/BI00391A002
关键词:
摘要: Recent studies in our laboratory [Tokuda, M., Khanna, N.C., Aurora, A., & Waisman, D. M. (1986) Biochem. Biophys. Res. Commun. 139, 910-917] have identified membranes of rat spleen two tyrosine protein kinases named TPK-I and TPK-II. In this paper the identification Ca2+ binding CAB-48 as a major vitro substrate TPK-II is reported. catalyzed incorporation 0.73 mol phosphate/mol CAB-48. Phosphoamino acid analysis revealed that phosphorylation was specific for residues. Phosphorylation by (rat spleen), kinase C, casein I, II, cAMP-dependent kinase, or calcium calmodulin dependent not observed.
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