The Functional Roles and Applications of Immunoglobulins in Neurodegenerative Disease.
作者： Kyu-Young Sim , Kyeong Chan Im , Sung-Gyoo Park
DOI: 10.3390/IJMS21155295
关键词:
摘要: Natural autoantibodies, immunoglobulins (Igs) that target self-proteins, are common in the plasma of healthy individuals; some autoantibodies play pathogenic roles systemic or tissue-specific autoimmune diseases, such as rheumatoid arthritis and lupus erythematosus. Recently, field autoantibody-associated diseases has expanded to encompass neurodegenerative Alzheimer's disease (AD) Parkinson's (PD), with related studies examining functions Igs central nervous system (CNS). Recent evidence suggests have various effects CNS; these associated prevention neurodegeneration, well induction. Here, we summarize functional respect (AD PD), focusing on antigens effector cell types. In addition, review current knowledge about antibodies diagnostic markers immunotherapies.
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Bruno Vellas, R. Black, Leon Thal, Nick Fox, M. Daniels, G. McLennan, C. Tompkins, C. Leibman, M. Pomfret, Michael Grundman, Long-term follow-up of patients immunized with AN1792: reduced functional decline in antibody responders. Current Alzheimer Research. ,vol. 6, pp. 144- 151 ,(2009) , 10.2174/156720509787602852
Ewa Papuć, Jacek Kurzepa, Ewa Kurys-Denis, Aneta Grabarska, Witold Krupski, Konrad Rejdak, Humoral response against glial derived antigens in Parkinson's disease Neuroscience Letters. ,vol. 566, pp. 77- 81 ,(2014) , 10.1016/J.NEULET.2014.02.043
Xi-Jin Wang, Zhi-Qiang Yan, Guo-Qiang Lu, Smith Stuart, Sheng-Di Chen, Parkinson disease IgG and C5a-induced synergistic dopaminergic neurotoxicity: role of microglia. Neurochemistry International. ,vol. 50, pp. 39- 50 ,(2007) , 10.1016/J.NEUINT.2006.07.014
Esther Parada, Javier Egea, Alejandro Romero, Laura del Barrio, Antonio G. García, Manuela G. López, Poststress treatment with PNU282987 can rescue SH-SY5Y cells undergoing apoptosis via α7 nicotinic receptors linked to a Jak2/Akt/HO-1 signaling pathway. Free Radical Biology and Medicine. ,vol. 49, pp. 1815- 1821 ,(2010) , 10.1016/J.FREERADBIOMED.2010.09.017
Madison T Gray, John M Woulfe, Striatal Blood–Brain Barrier Permeability in Parkinson'S Disease Journal of Cerebral Blood Flow and Metabolism. ,vol. 35, pp. 747- 750 ,(2015) , 10.1038/JCBFM.2015.32
Jessica L. Teeling, Roxana O. Carare, Martin J. Glennie, V. Hugh Perry, Intracerebral immune complex formation induces inflammation in the brain that depends on Fc receptor interaction. Acta Neuropathologica. ,vol. 124, pp. 479- 490 ,(2012) , 10.1007/S00401-012-0995-3
Ales Bartos, Lenka Fialová, Jana Švarcová, Daniela Ripova, Patients with Alzheimer disease have elevated intrathecal synthesis of antibodies against tau protein and heavy neurofilament. Journal of Neuroimmunology. ,vol. 252, pp. 100- 105 ,(2012) , 10.1016/J.JNEUROIM.2012.08.001
Constantin Bouras, Beat M. Riederer, Enikö Kövari, Patrick R. Hof, Panteleimon Giannakopoulos, Humoral immunity in brain aging and Alzheimer's disease. Brain Research Reviews. ,vol. 48, pp. 477- 487 ,(2005) , 10.1016/J.BRAINRESREV.2004.09.009
Eliezer Masliah, Edward Rockenstein, Michael Mante, Leslie Crews, Brian Spencer, Anthony Adame, Christina Patrick, Margarita Trejo, Kiren Ubhi, Troy T. Rohn, Sarah Mueller-Steiner, Peter Seubert, Robin Barbour, Lisa McConlogue, Manuel Buttini, Dora Games, Dale Schenk, Passive Immunization Reduces Behavioral and Neuropathological Deficits in an Alpha-Synuclein Transgenic Model of Lewy Body Disease PLoS ONE. ,vol. 6, pp. e19338- ,(2011) , 10.1371/JOURNAL.PONE.0019338
Madalina Maftei, Franka Thurm, Cathrin Schnack, Hayrettin Tumani, Markus Otto, Thomas Elbert, Iris-Tatjana Kolassa, Michael Przybylski, Marilena Manea, Christine AF von Arnim, None, Increased Levels of Antigen-Bound β-Amyloid Autoantibodies in Serum and Cerebrospinal Fluid of Alzheimer’s Disease Patients PLoS ONE. ,vol. 8, pp. e68996- ,(2013) , 10.1371/JOURNAL.PONE.0068996