Fasting Reduces KiSS‐1 Expression in the Anteroventral Periventricular Nucleus (AVPV): Effects of Fasting on the Expression of KiSS‐1 and Neuropeptide Y in the AVPV or Arcuate Nucleus of Female Rats

摘要: Changes in metabolic state, such as those induced by fasting, have profound effects on reproduction. In rats, the time-course over which fasting inhibits luteinising hormone (LH) release is reduced to 48 h presence of oestradiol-17beta (E(2)). Hypothalamic kisspeptin plays a key role mediating actions E(2) gonadotrophin-releasing (GnRH) neurones, and thereby promotes LH release. KiSS-1-expressing neurones are found anteroventral periventricular nucleus (AVPV) arcuate (ARC). Extensive evidence implicates AVPV GnRH ARC energy balance. The latter also contains that express neuropeptide Y (NPY), an orexigenic peptide implicated control. To elucidate involvement and/or NPY hypothalamic responses their expression was quantified situ hybridisation histochemistry ovariectomised with or without replacement, before after fasting. E(2), but not its absence, suppressed plasma LH. AVPV, low level KiSS-1 absence unaffected By contrast, elevated Independent had no effect ARC, increased at site. present study has identified site can be influenced results suggest inhibition may significant factor restraining gonadotrophic axis response negative balance oestrogen. extent concurrent rise contribute suppression influencing directly indirectly, independent kisspeptin, remains established.