摘要: The main objective of this review article is to overcome or improve the problems related with curcumin help new technologies modifications make a promising therapeutic agent which gives good response. Curcumin, known natural polyphenolic compound obtained from dietary spice turmeric, possesses pharmacologic effects including anti-inflammatory, antioxidant, and many other activities. Clinical trials on have shown its safety efficacy even at high doses in humans. But inspite that it shows poor bioavailability (oral bioavailability) one major regarding curcumin. There are reasons contributing low plasma tissue levels appear be due absorption, rapid metabolism, systemic elimination. To curcumin, numbers approaches been undertaken. These involve, first, use adjuvant like piperine interferes glucuronidation; second, liposomal curcumin; third, nanoparticles; fourth, phospholipids complex; fifth, structural analogues
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Akira Asai, Teruo Miyazawa, Occurrence of orally administered curcuminoid as glucuronide and glucuronide/sulfate conjugates in rat plasma Life Sciences. ,vol. 67, pp. 2785- 2793 ,(2000) , 10.1016/S0024-3205(00)00868-7
Kapil Mehta, Panayotis Pantazis, Theresa McQueen, Bharat B Aggarwal, ANTIPROLIFERATIVE EFFECT OF CURCUMIN (DIFERULOYLMETHANE) AGAINST HUMAN BREAST TUMOR CELL LINES Anti-Cancer Drugs. ,vol. 8, pp. 470- 481 ,(1997) , 10.1097/00001813-199706000-00010
Waree Tiyaboonchai, Watcharaphorn Tungpradit, Pinyupa Plianbangchang, Formulation and characterization of curcuminoids loaded solid lipid nanoparticles. International Journal of Pharmaceutics. ,vol. 337, pp. 299- 306 ,(2007) , 10.1016/J.IJPHARM.2006.12.043
Christopher D Lao, Marie-France Demierre, Vernon K Sondak, Targeting events in melanoma carcinogenesis for the prevention of melanoma Expert Review of Anticancer Therapy. ,vol. 6, pp. 1559- 1568 ,(2006) , 10.1586/14737140.6.11.1559
Alexa Teichmann, Sandra Heuschkel, Ute Jacobi, Gaëlle Presse, Reinhard H.H. Neubert, Wolfram Sterry, Jürgen Lademann, Comparison of stratum corneum penetration and localization of a lipophilic model drug applied in an o/w microemulsion and an amphiphilic cream. European Journal of Pharmaceutics and Biopharmaceutics. ,vol. 67, pp. 699- 706 ,(2007) , 10.1016/J.EJPB.2007.04.006
R.A. Sharma, A.J. Gescher, W.P. Steward, Curcumin: The story so far European Journal of Cancer. ,vol. 41, pp. 1955- 1968 ,(2005) , 10.1016/J.EJCA.2005.05.009
Asok Mukhopadhyay, Carlos Bueso-Ramos, Devasis Chatterjee, Panayotis Pantazis, Bharat B Aggarwal, Curcumin downregulates cell survival mechanisms in human prostate cancer cell lines Oncogene. ,vol. 20, pp. 7597- 7609 ,(2001) , 10.1038/SJ.ONC.1204997
P. Boriwanwattanarak, K. Ingkaninan, N. Khorana, J. Viyoch, Development of curcuminoids hydrogel patch using chitosan from various sources as controlled‐release matrix International Journal of Cosmetic Science. ,vol. 30, pp. 205- 218 ,(2008) , 10.1111/J.1468-2494.2008.00437.X
Sivaprakasam Balasubramanian, Richard L. Eckert, Green tea polyphenol and curcumin inversely regulate human involucrin promoter activity via opposing effects on CCAAT/enhancer-binding protein function. Journal of Biological Chemistry. ,vol. 279, pp. 24007- 24014 ,(2004) , 10.1074/JBC.M314331200
Bo Wahlström, G. Blennow, A study on the fate of curcumin in the rat Pharmacology & Toxicology. ,vol. 43, pp. 86- 92 ,(2009) , 10.1111/J.1600-0773.1978.TB02240.X