Phenoxy-Pyrrolidine Derivative and Its Use and Compositions
作者： Nicole Lee Kolosko , Jin Li
DOI:
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摘要: The present invention is directed to the compound 2-(4-(hydroxymethyl)phenoxy)-1-(3-(2-(trifluoromethyl)phenoxy)pyrrolidin-1-yl)ethanone, its use as an inhibitor of stearoyl CoA desaturase and pharmaceutical compositions containing this compound.
lens.org参考文章(16)
Drew G. Doblar, Han Y. Ko, Computer system providing low skew clock signals to a synchronous memory unit ,(1999)
Vishnumurthy Kodumuru, Serguei V. Sviridov, Shaoyi Sun, Melwyn Abreo, Shifeng Liu, Chi Tu, Wenbao Li, Michael D. Winther, Rajender K. Kamboj, Heinz W. Gschwend, Mark W. Holladay, Piperazine derivatives and their use as therapeutic agents ,(2004)
Jean-Philippe Leclerc, Chun Sing Li, Yeeman K. Ramtohul, Heteroaromatic Compounds As Inhibitors Of Stearoyl-Coenzyme A Delta-9 Desaturase ,(2006)
Natalia Scaglia, R. Ariel Igal, Stearoyl-COA desaturase is involved in the control of proliferation, anchorage-independent growth and survival in human transformed cells Journal of Biological Chemistry. ,vol. 280, pp. 25339- 25349 ,(2005) , 10.1074/JBC.M501159200
Natalia Scaglia, J. Matías Caviglia, R. Ariel Igal, High stearoyl-CoA desaturase protein and activity levels in simian virus 40 transformed-human lung fibroblasts. Biochimica et Biophysica Acta. ,vol. 1687, pp. 141- 151 ,(2005) , 10.1016/J.BBALIP.2004.11.015
Harini Sampath, Makoto Miyazaki, Agnieszka Dobrzyn, James M. Ntambi, Stearoyl-CoA Desaturase-1 Mediates the Pro-lipogenic Effects of Dietary Saturated Fat Journal of Biological Chemistry. ,vol. 282, pp. 2483- 2493 ,(2007) , 10.1074/JBC.M610158200
Paul Cohen, Makoto Miyazaki, Nicholas D Socci, Aaron Hagge-Greenberg, Wolfgang Liedtke, Alexander A Soukas, Ratnendra Sharma, Lisa C Hudgins, James M Ntambi, Jeffrey M Friedman, Role for Stearoyl-CoA Desaturase-1 in Leptin-Mediated Weight Loss Science. ,vol. 297, pp. 240- 243 ,(2002) , 10.1126/SCIENCE.1071527
Qing Dallas-Yang, Thomas Doebber, Kenneth Ellsworth, Franklin Liu, Deborah Szalkowski, Zhihua Li, Raynald Bergeron, Margaret Wu, John Ronan, Bei B. Zhang, Cain Murphy, Christine Esau, Guoqiang Jiang, Prevention of obesity in mice by antisense oligonucleotide inhibitors of stearoyl-CoA desaturase-1 Journal of Clinical Investigation. ,vol. 115, pp. 1030- 1038 ,(2005) , 10.1172/JCI23962
Vishnumurthy Kodumuru, Boris Klebansky, Richard M. Fine, Shaoyi Sun, Jian-Min Fu, Mark P. Gray-Keller, Daniel F. Harvey, Wenbao Li, Michael D. Winther, Heinz W. Gschwend, Nicotinamide derivatives and their use as therapeutic agents ,(2004)
J. M. Ntambi, M. Miyazaki, J. P. Stoehr, H. Lan, C. M. Kendziorski, B. S. Yandell, Y. Song, P. Cohen, J. M. Friedman, A. D. Attie, Loss of stearoyl–CoA desaturase-1 function protects mice against adiposity Proceedings of the National Academy of Sciences of the United States of America. ,vol. 99, pp. 11482- 11486 ,(2002) , 10.1073/PNAS.132384699