Is FTO a type 2 diabetes susceptibility gene

M. J. Müller, A. Bosy-Westphal, M. Krawczak, Genetic studies of common types of obesity: a critique of the current use of phenotypes. Obesity Reviews. ,vol. 11, pp. 612- 618 ,(2010) , 10.1111/J.1467-789X.2010.00734.X

Struan F A Grant, Gudmar Thorleifsson, Inga Reynisdottir, Rafn Benediktsson, Andrei Manolescu, Jesus Sainz, Agnar Helgason, Hreinn Stefansson, Valur Emilsson, Anna Helgadottir, Unnur Styrkarsdottir, Kristinn P Magnusson, G Bragi Walters, Ebba Palsdottir, Thorbjorg Jonsdottir, Thorunn Gudmundsdottir, Arnaldur Gylfason, Jona Saemundsdottir, Robert L Wilensky, Muredach P Reilly, Daniel J Rader, Yu Bagger, Claus Christiansen, Vilmundur Gudnason, Gunnar Sigurdsson, Unnur Thorsteinsdottir, Jeffrey R Gulcher, Augustine Kong, Kari Stefansson, Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes Nature Genetics. ,vol. 38, pp. 320- 323 ,(2006) , 10.1038/NG1732

Nicole J. Poritsanos, Pei San Lew, Tooru M. Mizuno, Relationship between blood glucose levels and hepatic Fto mRNA expression in mice. Biochemical and Biophysical Research Communications. ,vol. 400, pp. 713- 717 ,(2010) , 10.1016/J.BBRC.2010.08.133

Izumi Shimaoka, Kei Kamide, Mitsuru Ohishi, Tomohiro Katsuya, Hiroshi Akasaka, Shigeyuki Saitoh, Ken Sugimoto, Ryousuke Oguro, Ada Congrains, Tomomi Fujisawa, Kazuaki Shimamoto, Toshio Ogihara, Hiromi Rakugi, Association of gene polymorphism of the fat-mass and obesity-associated gene with insulin resistance in Japanese Hypertension Research. ,vol. 33, pp. 214- 218 ,(2010) , 10.1038/HR.2009.215

A. E. Pontiroli, L. Miele, A. Morabito, Increase of body weight during the first year of intensive insulin treatment in type 2 diabetes: systematic review and meta-analysis. Diabetes, Obesity and Metabolism. ,vol. 13, pp. 1008- 1019 ,(2011) , 10.1111/J.1463-1326.2011.01433.X

Anke Hinney, Thuy Trang Nguyen, André Scherag, Susann Friedel, Günter Brönner, Timo Dirk Müller, Harald Grallert, Thomas Illig, H-Erich Wichmann, Winfried Rief, Helmut Schäfer, Johannes Hebebrand, None, Genome Wide Association (GWA) Study for Early Onset Extreme Obesity Supports the Role of Fat Mass and Obesity Associated Gene (FTO) Variants PLoS ONE. ,vol. 2, pp. e1361- ,(2007) , 10.1371/JOURNAL.PONE.0001361

L De Koning, HC Gerstein, J Bosch, R Diaz, V Mohan, G Dagenais, S Yusuf, SS Anand, EpiDREAM Investigators, None, Anthropometric measures and glucose levels in a large multi-ethnic cohort of individuals at risk of developing type 2 diabetes Diabetologia. ,vol. 53, pp. 1322- 1330 ,(2010) , 10.1007/S00125-010-1710-3

Katherine Samaras, Natalia K. Botelho, Donald J. Chisholm, Reginald V. Lord, Subcutaneous and Visceral Adipose Tissue FTO Gene Expression and Adiposity, Insulin Action, Glucose Metabolism, and Inflammatory Adipokines in Type 2 Diabetes Mellitus and in Health Obesity Surgery. ,vol. 20, pp. 108- 113 ,(2010) , 10.1007/S11695-009-9952-1

Mark I. McCarthy, Genomics, Type 2 Diabetes, and Obesity The New England Journal of Medicine. ,vol. 363, pp. 2339- 2350 ,(2010) , 10.1056/NEJMRA0906948

Christian Dina, David Meyre, Sophie Gallina, Emmanuelle Durand, Antje Körner, Peter Jacobson, Lena M S Carlsson, Wieland Kiess, Vincent Vatin, Cecile Lecoeur, Jérome Delplanque, Emmanuel Vaillant, François Pattou, Juan Ruiz, Jacques Weill, Claire Levy-Marchal, Fritz Horber, Natascha Potoczna, Serge Hercberg, Catherine Le Stunff, Pierre Bougnères, Peter Kovacs, Michel Marre, Beverley Balkau, Stéphane Cauchi, Jean-Claude Chèvre, Philippe Froguel, Variation in FTO contributes to childhood obesity and severe adult obesity Nature Genetics. ,vol. 39, pp. 724- 726 ,(2007) , 10.1038/NG2048