Extracellular Matrix Biomarkers of Adverse Remodeling after Myocardial Infarction

摘要: Approximately every minute, someone will die from a myocardial infarction (MI). A MI is the result of an obstruction blood supply causing heart to undergo complex structural and functional changes in left ventricular wall, known as remodeling. Cardiomyocytes necrosis rapidly after onset injury, leading early accumulation neutrophils, activation metalloproteinases, degradation stromal tissue, eventually formation collagen scar. Circulating factors related inflammatory fibrotic responses are key predictors extracellular matrix (ECM) that occur MI. Changes network ECM can alter stiffness, consequently cardiac hypertrophy, fibrosis, LV dysfunction. Proteins peptides promising biomarkers for This book chapter provides overview involved adverse remodeling post-MI their practical applications.