A sensitive and specific radiometric method for the measurement of plasma histamine in normal individuals.
作者： M.J. Brown , P.W. Ind , P.J. Barnes , D.A. Jenner , C.T. Dollery
DOI: 10.1016/0003-2697(80)90022-6
关键词:
摘要: Abstract A radioenzymatic method for assaying histamine using histamine-N-methyltransferase from guinea pig brain was modified to increase its sensitivity, precision, and specificity. This achieved by incorporation of a thin-layer chromatography step use Nα-methyl as an internal standard in each sample. No prior extraction the plasma samples is required, permitting assay 30 1 working day. Histamine detected 17 normal volunteers, at level 3.4 ± 0.69 nmol/liter (range 0.82 4.7 nmol/liter). In 19 asthmatics, low-peak expiratory flow rate found be associated with concentration above this “normal” range.
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