Super-hydrophilic and high strength polymeric foam dressings of modified chitosan blends for topical wound delivery of chloramphenicol.

摘要: Abstract In the present study polymer blends based on chitosan (CS) and its derivatives with trans-aconitic (t-Acon) acid another trimellitic (TRM) anhydride, were prepared for topical wound delivery of chloramphenicol (CHL). FT-IR spectroscopy revealed successful grafting t-Acon or TRM anhydride into CS macromolecules at molar ratios 1:1 1:0.5, while powder X-ray diffraction (XRD) analysis showed that materials amorphous. Neat grafted mixed in different (25/75, 50/50 75/25 w/w) order to prepare suitable blends. Scanning electron microscopy (SEM) formed after freeze-drying had a sponge-like structure, thermogravimetric (TGA) verified their thermal stability. All are miscible studied compositions have extensive swelling much better mechanical properties than neat CS. further step, obtained porous sponges from CS/CS-derivatives 50/50 w/w loaded Chloramphenicol (10, 20 30 wt%), broad-spectrum antibiotic, dressings evaluated terms FT-IR, XRD, SEM, vitro drug dissolution. An initial burst release followed by quasi-Fickian diffusion driven sustained phase was observed addition gives high antimicrobial all dressings.