The role of the CD39–CD73–adenosine pathway in liver disease

摘要: Extracellular adenosine triphosphate (ATP) is a danger signal released by dying and damaged cells, it functions as an immunostimulatory that promotes inflammation. The ectonucleotidases CD39/ectonucleoside diphosphohydrolase-1 CD73/ecto-5'-nucleotidase are cell-surface enzymes breakdown extracellular ATP into adenosine. This drives shift from ATP-driven proinflammatory environment to anti-inflammatory milieu induced CD39-CD73-adenosine pathway changes dynamically with the pathophysiological context in which embedded. Accumulating evidence suggests CD39 CD73 play important roles liver disease critical components of adenosinergic pathway. Recent studies have shown modification alters liver's response injury. Moreover, exerts different effects on pathophysiology through receptors. In this review, we aim describe role receptors disease, highlighting potential therapeutic targets pathway, will facilitate development strategies for treatment disease.