Core-Shell Structured Antimicrobial Nanofiber Dressings Containing Herbal Extract and Antibiotics Combination for the Prevention of Biofilms and Promotion of Cutaneous Wound Healing.

摘要: Burn wounds are susceptible to microbial invasion from both resident and exogenous bacteria, which becomes a critical public health issue causes substantial economic burden. There is perceived demand produce new antimicrobial wound dressings that hinder bacterial colonization while accelerating the healing process hence would provide an improved standard of care for patients. Since ancient times, herbal extracts medicinally important plants have extensively been used treating burn injuries. This work reports utility electrospun nanofibers containing plant antibiotics combination as multifunctional scaffold second-degree burns. First, we determined various components Gymnema sylvestre by two different processing methods their synergism with minocycline antibiotics. Then, prepared core-shell nanofibrous poly-e-caprolactone/gelatin laden hydrochloride shell gelatin infused G. (ultrasound-assisted cold macerated extracts) core using coaxial electrospinning. The displayed smooth, continuous, bead-free morphology adequate wettability. presence extract in resulted enhanced mechanical properties when compared pristine mats. structures sustained release bioactive nanofiber blends. Core-shell mats antibiotic combinations potent antibiofilm promoting spread proliferation skin cells In porcine model cutaneous burns, showed treated dressing re-epithelialization collagen organization comparison untreated wounds.