Molecular Determinants of Influenza Virus Pathogenesis in Mice

摘要: Mice are widely used for studying influenza virus pathogenesis and immunology because of their low cost, the wide availability mouse-specific reagents, large number mouse strains available, including knockout transgenic strains. However, mice do not fully recapitulate signs infection humans: transmission between is much less efficient than in humans, viruses often require adaptation before they able to efficiently replicate mice. In process adaptation, acquire mutations that enhance ability attach cells, within suppress immunity, among other functions. Many such mouse-adaptive have been identified, covering all 8 genomic segments virus. Identification analysis these provided insight into molecular determinants virulence pathogenesis, only but also humans species. particular, several avian proved be general mammalian-adaptive changes potential markers pre-pandemic viruses. As well as evaluating models evaluation novel vaccines anti-viral therapies. can a useful animal model biology long differences human infections taken account.