Novel Neurotransmitters and the Chemical Coding of Neurones

摘要: It took many years, from 1904 to the middle 1950’s, firmly establish chemical transmission as a fact and demonstrate involvement of acetylcholine noradrenaline transmitter substances. There followed period re-evaluation pharmacology using antagonists cholinergic noradrenergic transmission. This led stage, in 1960’s, where number processes that did not seem depend on either these substances were recognized. Then, late 1970’s, immunochemical other methods discovery numerous potential central peripheral neurones. A major further has been neurones frequently contain two or more (neuronal markers) are, may be, involved process. Furthermore, patterns association neuronal markers indicate there is coding functionally subdivides similar according classes species animals, targets they supply. The interactions between are together neurotransmission suggests plurichemical process In which released cause acute changes excitability, enhance each other’s effectiveness, prolong curtail events target cells.