Gut mucosal immunostimulation by lactic acid bacteria.

摘要: The beneficial properties of lactic acid bacteria (LAB) on human health have been frequently demonstrated. interaction LAB with the lymphoid cells associated to gut activate mucosal immune system and mechanisms by which they can exert an adjuvant effect is still unclear, as well if this property common for all LAB. We studied influence oral administration different geneous such Lactobacillus casei, L. acidophilus, rhamnosus, delbrueckii subsp. bulgaricus, plantarum, Lactococcus lactis Streptococcus thermophilus. determined assayed were able stimulate specific, non-specific response (inflammatory response), or both. demonstrated that increase number IgA producing lamina propria small intestine. This was dose dependent. in IgA+ not always correlated CD4+ T cell number, indicating some only induced clonal expansion B triggered produce IgA. Most them, involved inflammatory response. CD8+ diminished affected, exception plantarum at low dose. fact would mean are unable induce cytotoxicity mechanisms. importance selection be used adjuvant. behaviours observed among them response, specially those show generalized genous specie. immunoadjuvant capacity a strain assayed.