A New Role for Ran in Ensuring Precise Duplication of Chromosomal DNA

作者: J.Julian Blow

DOI: 10.1016/S0092-8674(03)00236-8

关键词:

摘要: To prevent re-replication of DNA, the licensing replication origins is inhibited in S phase and G2. New work by Yamaguchi et al. (in this issue Cell) shows that small GTPase Ran can directly inhibit inside nuclei once CDKs are active late cell cycle.

参考文章(11)
Van Q. Nguyen, Carl Co, Joachim J. Li, Cyclin-dependent kinases prevent DNA re-replication through multiple mechanisms. Nature. ,vol. 411, pp. 1068- 1073 ,(2001) , 10.1038/35082600
Jérôme Wuarin, Vicky Buck, Paul Nurse, Jonathan B.A. Millar, Stable Association of Mitotic Cyclin B/Cdc2 to Replication Origins Prevents Endoreduplication Cell. ,vol. 111, pp. 419- 431 ,(2002) , 10.1016/S0092-8674(02)01042-5
Hideo Nishitani, Zoi Lygerou, Control of DNA replication licensing in a cell cycle Genes to Cells. ,vol. 7, pp. 523- 534 ,(2002) , 10.1046/J.1365-2443.2002.00544.X
Seiji Tanaka, John F.X. Diffley, Interdependent nuclear accumulation of budding yeast Cdt1 and Mcm2-7 during G1 phase. Nature Cell Biology. ,vol. 4, pp. 198- 207 ,(2002) , 10.1038/NCB757
Johannes Walter, Li Sun, John Newport, Regulated Chromosomal DNA Replication in the Absence of a Nucleus Molecular Cell. ,vol. 1, pp. 519- 529 ,(1998) , 10.1016/S1097-2765(00)80052-0
Ryuji Yamaguchi, John Newport, A Role for Ran-GTP and Crm1 in Blocking Re-Replication Cell. ,vol. 113, pp. 115- 125 ,(2003) , 10.1016/S0092-8674(03)00200-9
Ben Hodgson, Anatoliy Li, Shusuke Tada, J. Julian Blow, Geminin Becomes Activated as an Inhibitor of Cdt1/RLF-B Following Nuclear Import Current Biology. ,vol. 12, pp. 678- 683 ,(2002) , 10.1016/S0960-9822(02)00778-9
P. V. Jallepalli, G. W. Brown, M. Muzi-Falconi, D. Tien, T. J. Kelly, Regulation of the replication initiator protein p65cdc18 by CDK phosphorylation Genes & Development. ,vol. 11, pp. 2767- 2779 ,(1997) , 10.1101/GAD.11.21.2767
Amit Vas, Winnie Mok, Janet Leatherwood, Control of DNA rereplication via Cdc2 phosphorylation sites in the origin recognition complex. Molecular and Cellular Biology. ,vol. 21, pp. 5767- 5777 ,(2001) , 10.1128/MCB.21.17.5767-5777.2001