Effect of Nicotine on the Coronary Blood Flow and Related Circulatory Parameters CORRELATIVE STUDY IN NORMAL DOGS AND DOGS WITH CORONARY INSUFFICIENCY

摘要: The effect of intravenously administered nicotine (20 µg ./Kg./min.) on the coronary blood flow and related hemodynamic parameters was studied in normal intact dog with chronic insufficiency as produced either by artery ligation or gradual narrowing. Nicotine increases cardiac work markedly an increase mean arterial pressure output. degree this is similar dogs arid insufficiency. control moderately decreased narrowing two main branches left coronaryatery. which observed to be high 125 per cent average over value. consider ably less one branch (82.5 cent) (83.3 cent). and/or occlusion directly response flow; greater impairment, smaller increment corollary frequently dropped below value postinfusion period, Coronary vascular resistance myocardial oxygen utilization declined during event administration. resembled that anoxemia presence These findings would appear have a bearing clinical problem relative human subject disease.