Directing Assembly and Disassembly of 2D MoS2 Nanosheets with DNA for Drug Delivery

摘要: Layer-by-layer (LbL) self-assembled stacked Testudo-like MoS2 superstructures carrying cancer drugs are formed from nanosheets controllably assembled with sequence-based DNA oligonucleotides. These can disassemble autonomously in response to cells’ heightened ATP metabolism. First, we functionalize (MoS2-NS) nanostructures oligonucleotides having thiol-terminated groups (DNA/MoS2-NS) via strong binding sulfur atom defect vacancies on surfaces. The driving force assemble into a higher-order DNA/MoS2-NS superstructure is guided by linker aptamer that induced interlayer assembly. In the presence of target molecules, these multilayer disassembled as consequence stronger molecules linking aptamers. This design plays dual role protection and delivery LbL MoS2-NS similar concept Greek Testudo. present protective armor-like shell MoS2-NS, which still rema...