Environmental enrichment and working memory tasks decrease hippocampal cell proliferation after wheel running – A role for the prefrontal cortex in hippocampal plasticity?

摘要: Despite an increasing amount of evidence about the regulation adult hippocampal neurogenesis on local level, less attention has been paid to its systemic embedding in wider brain circuits. The aim present study was obtain for a potential role prefrontal cortex neurogenesis. We hypothesised that activation by environmental enrichment or working-memory task would decrease previously enhanced cell proliferation rates. Wheel running applied as common stimulator CD1 mice reared under deprivation natural stimulation. Next, animals were assigned four groups different treatments following three days: housing continued deprivation, enrichment, spatial-delayed alternation automated T-maze activates requirements control differing only single parameter working-memory-associated delay. Both and tasks decreased rates dentate gyrus compared deprived T-maze. As underwent same procedures stressors differed delay, requirement seems be crucial factor decreasing Taken together, these results suggest may play proliferation.