Familial and sporadic human renal cell carcinoma: Evidence against a double-loss mechanism of carcinogenesis
作者： Wilfred D. Stein , Aryeh D. Stein
DOI: 10.1016/0895-4356(94)00192-S
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摘要: It has been speculated that renal cell carcinoma (RCC) is an example of a double-loss mutation. We analyzed the age distribution 71 cases familial RCC and 11 population-based cancer registries [German Democratic Republic, Denmark, Finland, Norway, Sweden, U.S.A. Whites, Blacks, Miyagi Osaka Prefectures (Japan), Hong Kong, Israeli Jews] according to multi-hit clonal growth models carcinogenesis. The analysis rules out mechanism for RCC. On both two analyzed, carcinogenesis in arises as result three- ten-fold increase average rate mutation at susceptible loci, compared with sporadic cases. In general, model provides somewhat better fit age-distribution incidence than does model.
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sci-hub.se 参考文章(45)
M M Gottesman, I Pastan, The multidrug transporter, a double-edged sword. Journal of Biological Chemistry. ,vol. 263, pp. 12163- 12166 ,(1988) , 10.1016/S0021-9258(18)37730-5
W.D. Stein, Analysis of cancer incidence data on the basis of multistage and clonal growth models. Advances in Cancer Research. ,vol. 56, pp. 161- 213 ,(1991) , 10.1016/S0065-230X(08)60481-9
E. Steliarova-Foucher, M. Laversanne, J. Ferlay, D. Forman, S. Antoni, Freddie Ian Bray, C. Gombe Mbalawa, B. Kohler, M. Piñeros, D. H. Brewster, I. Soerjomataram, R. Swaminathan, Cancer Incidence in Five Continents ,(1997)
Jeffrey V. Sutherl, John C. Bailar, The multihit model of carcinogenesis: Etiologic implications for colon cancer Journal of Chronic Diseases. ,vol. 37, pp. 465- 480 ,(1984) , 10.1016/0021-9681(84)90030-4
Two-Stage Model for Carcinogenesis: Epidemiology of Breast Cancer in Females Journal of the National Cancer Institute. ,vol. 65, pp. 559- 569 ,(1980) , 10.1093/JNCI/65.3.559
Suresh H. Moolgavkar, Alfred G. Knudson, Mutation and Cancer: A Model for Human Carcinogenesis2 JNCI: Journal of the National Cancer Institute. ,vol. 66, pp. 1037- 1052 ,(1981) , 10.1093/JNCI/66.6.1037
P. W. MATHIESON, Renal carcinoma with a strong family history. BJUI. ,vol. 58, pp. 458- 459 ,(1986) , 10.1111/J.1464-410X.1986.TB09108.X
S Pathak, LC Strong, RE Ferrell, A Trindade, Familial renal cell carcinoma with a 3 ; 11 chromosome translocation limited to tumor cells Science. ,vol. 217, pp. 939- 941 ,(1982) , 10.1126/SCIENCE.7112106
Andrew J. Cohen, Frederick P. Li, Solomon Berg, David J. Marchetto, Shien Tsai, Stephen C. Jacobs, Robert S. Brown, Hereditary Renal-Cell Carcinoma Associated with a Chromosomal Translocation New England Journal of Medicine. ,vol. 301, pp. 592- 595 ,(1979) , 10.1056/NEJM197909133011107
Leonard Horn, HillelL. Horn, AN IMMUNOLOGICAL APPROACH TO THE THERAPY OF CANCER The Lancet. ,vol. 298, pp. 466- 470 ,(1971) , 10.1016/S0140-6736(71)92632-8