作者: M. Bazhenov , I. Timofeev , M. Steriade , T.J. Sejnowski
DOI: 10.1038/5729
关键词:
摘要: Intracellular recordings from reticular thalamic (RE) neurons in vivo revealed inhibitory postsynaptic potentials (IPSPs) between RE cells that reversed and became depolarizing at the hyperpolarized membrane occur during sleep. These excitatory IPSPs can directly trigger low-threshold spikes (LTSs). The oscillatory mechanisms underlying IPSP-triggered LTSs crowned by spike bursts were investigated models of isolated networks. In a one-dimensional network model, external stimulation evoked waves excitation propagating constant velocity 25‐150 per second. large-scale, two-dimensional model nucleus, showed transient or self-sustained oscillations controlled maximum conductance calcium current potential. This predicts nucleus could initiate sequences spindle thalamocortical networks vivo.