Self-sustained rhythmic activity in the thalamic reticular nucleus mediated by depolarizing GABA A receptor potentials

作者: M. Bazhenov , I. Timofeev , M. Steriade , T.J. Sejnowski

DOI: 10.1038/5729

关键词:

摘要: Intracellular recordings from reticular thalamic (RE) neurons in vivo revealed inhibitory postsynaptic potentials (IPSPs) between RE cells that reversed and became depolarizing at the hyperpolarized membrane occur during sleep. These excitatory IPSPs can directly trigger low-threshold spikes (LTSs). The oscillatory mechanisms underlying IPSP-triggered LTSs crowned by spike bursts were investigated models of isolated networks. In a one-dimensional network model, external stimulation evoked waves excitation propagating constant velocity 25‐150 per second. large-scale, two-dimensional model nucleus, showed transient or self-sustained oscillations controlled maximum conductance calcium current potential. This predicts nucleus could initiate sequences spindle thalamocortical networks vivo.

参考文章(43)
Arthur Winfree, When time breaks down ,(1987)
M. Steriade, M. Deschenes, L. Domich, C. Mulle, Abolition of spindle oscillations in thalamic neurons disconnected from nucleus reticularis thalami Journal of Neurophysiology. ,vol. 54, pp. 1473- 1497 ,(1985) , 10.1152/JN.1985.54.6.1473
Rodolfo R. Llinás, Edward G. Jones, Mircea Steriade, Thalamic oscillations and signaling. John Wiley & Sons. ,(1990)
Richard Miles, Roger D. Traub, Neuronal Networks of the Hippocampus ,(1991)
R. A. Nicoll, R. C. Malenka, J. A. Kauer, Functional comparison of neurotransmitter receptor subtypes in mammalian central nervous system Physiological Reviews. ,vol. 70, pp. 513- 565 ,(1990) , 10.1152/PHYSREV.1990.70.2.513
M. Steriade, L. Domich, G. Oakson, M. Deschenes, The deafferented reticular thalamic nucleus generates spindle rhythmicity Journal of Neurophysiology. ,vol. 57, pp. 260- 273 ,(1987) , 10.1152/JN.1987.57.1.260
I. Timofeev, M. Steriade, Low-frequency rhythms in the thalamus of intact-cortex and decorticated cats. Journal of Neurophysiology. ,vol. 76, pp. 4152- 4168 ,(1996) , 10.1152/JN.1996.76.6.4152
David Golomb, Yael Amitai, Propagating Neuronal Discharges in Neocortical Slices: Computational and Experimental Study Journal of Neurophysiology. ,vol. 78, pp. 1199- 1211 ,(1997) , 10.1152/JN.1997.78.3.1199