Vitamin D deficiency is a potential risk factor for contrast-induced nephropathy

摘要: Vitamin D deficiency (VDD) is widespread in the general population. Iodinated (IC) or gadolinium-based contrast media (Gd) may decrease renal function high-risk patients. This study tested hypothesis that VDD a predisposing factor for IC- Gd-induced nephrotoxicity. To this end, male Wistar rats were fed standard (SD) vitamin D-free diet 30 days. IC (diatrizoate), Gd (gadoterate meglumine), 0.9% saline was then administered intravenously and six groups obtained as following: SD plus (Sham-SD), (SD+IC), (SD+Gd), days (Sham-VDD30), (VDD30+IC), (VDD30+Gd). Renal hemodynamics, redox status, histological, immunoblot analysis evaluated 48 h after (CM) vehicle infusion. showed lower levels of total serum 25-hydroxyvitamin [25(OH)D], similar plasma calcium phosphorus concentration, higher renin angiotensinogen protein expression compared with SD. infusion did not affect inulin clearance-based estimated glomerular filtration rate (GFR) but significantly decreased GFR diet. Both CM increased angiotensinogen, interaction between triggered endothelial nitric oxide synthase abundance thiobarbituric acid reactive substances-to-glutathione ratio (an index oxidative stress) on VDD30+IC VDD30+Gd groups. Conversely, worsening accompanied by abnormalities kidney structure. Additionally, 60 displayed greater fall administration. Collectively, our findings suggest potential risk nephrotoxicity most likely due to imbalance intrarenal vasoactive substances stress.