Statistical interpretations and new findings on Variation in Cancer Risk Among Tissues

摘要: Tomasetti and Vogelstein (2015a) find that the incidence of a set cancer types is correlated with total number normal stem cell divisions. Here, we separate effects standing (i.e., organ or tissue size) per lifetime replication rate. We show each has statistically significant independent effect on explaining variation in over 31 cases considered by Vogelstein. When considering divisions when removing associated disease carcinogens, attains plateau approximately 0.6% for these authors. further demonstrate grouping anatomical site explains most remaining risk between types. This new analysis suggests depends not only but varies enormously ($\sim$10,000 times) depending cell's environment. Future research should investigate how characteristics (anatomical site, type, size, divisions) explain wider range cancers, to what extent different tissues express specific protective mechanisms, whether any differential protection can be attributed natural selection.