Oral iron acutely elevates bacterial growth in human serum.

摘要: Iron deficiency is the most common nutrient worldwide and routine supplementation standard policy for pregnant mothers children in low-income countries. However, iron lies at center of host-pathogen competition nutritional resources recent trials administration African Asian have resulted significant excesses serious adverse events including hospitalizations deaths. Increased rates malaria, respiratory infections, severe diarrhea febrile illnesses unknown origin all been reported, but mechanisms are unclear. We here investigated ex vivo growth characteristics exemplar sentinel bacteria adult sera collected before 4 h after oral with 2 mg/kg as ferrous sulfate. Escherichia coli, Yersinia enterocolitica Salmonella enterica serovar Typhimurium (all gram-negative bacteria) Staphylococcus epidermidis (gram-positive) showed markedly elevated serum supplementation. Growth were very strongly correlated transferrin saturation (p < 0.0001 cases). aureus, which preferentially scavenges heme iron, was unaffected. These data suggest that even modest supplements highly soluble (non-physiological) typically used settings, could promote bacteremia by accelerating early phase bacterial prior to induction immune defenses.