The association of adult lifecourse body mass index, waist circumference and dietary patterns with type 2 diabetes incidence in the MRC National Survey of Health and Development

摘要: Type 2 diabetes is a major public health problem and its prevalence increasing worldwide, especially among older people. Overweight abdominal obesity are known risk factors for the disease, but few studies have analysed their longitudinal pattern. A high glycaemic index (GI), low dietary fibre fats also been linked to type diabetes, combined effect has never studied. Using data from MRC National Survey of Health Development this thesis aimed examine adult life course (from age 26 53 years) body mass (BMI), waist circumference (WC) patterns in relation incidence between 60-64 years. At any stage BMI gain was associated with incidence. Early (26-36 late (43-53 adulthood gains were more important men whereas had stronger associations women. The increased longer durations overweight or obesity, probably because accumulation weight across course. Long-term WC change (36-53 years), independent concomitant change, women people an initially normal BMI. fat, GI, pattern identified that characterised by consumption refined grains, processed meat, animal fats, intake fruits, vegetables, low-fat dairy wholegrain cereals. Higher scores at 43 (only women) incidence, predominantly via pathways WC. score significantly only interventions reduce improve would be effective strategies prevent ages.