Survey of the effect of biotin on glycemic control and plasma lipid concentrations in type 1 diabetic patients in kermanshah in iran (2008-2009).

摘要: Objective: Diabetes mellitus is the most common chronic endocrine disease worldwide. Intensive glycemic control plays an important role in decreasing morbidity and mortality rate of disease. Preclinical studies have shown that biotin has essential regulating blood glucose serum lipid metabolism. This study aims to evaluate effect on plasma lipids concentrations type 1diabetic patients. Methods: randomized double-blind placebo-controlled clinical trial was conducted 70 1 diabetic patients with age range 5-25 years old poorly controlled (glycosylated hemoglobin ≥8%). Subjects were randomly allocated into two groups. In intervention group (40 microgram/kg) administered plus daily insulin, while received placebo insulin regimen for three months. Laboratory tests including glycosylated (HbA1c), fasting sugar measured at base after 3 months. Results: this study, seventy evaluated, 35 each group. There no statistically significant differences between age, gender, duration diabetes, BMI BP groups (p>0.05). HbA1c (biotin) 9.84±1.80 months treatment, it declined 8.88±1.73 (p<0.001). 9.39±1.58, increased to10.11± 1.68. mean both FBS 275±65.76 mg/dl had reduced 226± 41.31 total cholesterol, low density lipoprotein cholesterol triglyceride end (p<0.05). Conclusion: Results showed administration as adjuvant addition can improve management decrease patients.